898 articles
A protein called GPNMB and its receptor RYK drive fatty liver disease (MASH) in mice and humans. Blocking this pathway with various treatments effectively prevented and treated MASH in animal models, identifying a promising new therapeutic target.
A new base-editing therapy corrected a mutation in mice modeling a neurodevelopmental disorder, restoring protein levels and improving symptoms, with promising results in primates.
Cryo-EM shows microtubules drive assembly of a dynein-dynactin motor complex, while adaptors can later join. LIS1 regulator stabilizes intermediates, priming the machinery for transport.
The brain uses complex mRNA translation regulation. A new method, Ribo-STAMP, created the first isoform-sensitive, single-cell translatomes of the mouse hippocampus. It revealed thousands of cell-type-specific translated transcripts and differential translation states in neurons, advancing understanding of brain function and disease.
A genetic variant reduces CCND3 expression in red blood cells, increasing their size and decreasing their number. This impairs malaria parasite growth via reactive oxygen species, revealing a protective mechanism.
An mRNA vaccine targeting neoantigens induced strong, long-lasting T cell responses in triple-negative breast cancer patients. Most remained cancer-free for years, with insights into why a few relapsed.
Organic batteries with a new conducting polymer cathode offer high performance, safety, and sustainability, operating in extreme temperatures and for wearable tech.
STARLING is a new AI tool that quickly generates accurate structural ensembles for disordered proteins, enabling rapid analysis and design.
Oyster reefs' 3D structure, specifically certain fractal dimension and height combinations, maximizes survival by reducing predation. This guides restoration efforts.
Rising CO2, not nitrogen deposition, is causing declining nitrogen availability in Swedish boreal forests, impacting their future carbon sink capacity.
Researchers created a new all-polymer nanocomposite that achieves high energy storage at extreme temperatures, overcoming long-standing limitations in dielectric materials.
Microsoft created a long-lasting data storage system using glass.